Author's response to reviews Title:Determination of respiratory gas flow by electrical impedance tomography in an animal model of mechanical ventilation Authors:
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Determination of respiratory gas flow by electrical impedance tomography in an animal model of mechanical ventilation
BACKGROUND A recent method determines regional gas flow of the lung by electrical impedance tomography (EIT). The aim of this study is to show the applicability of this method in a porcine model of mechanical ventilation in healthy and diseased lungs. Our primary hypothesis is that global gas flow measured by EIT can be correlated with spirometry. Our secondary hypothesis is that regional analy...
متن کاملMechanical ventilation guided by electrical impedance tomography in experimental acute lung injury.
OBJECTIVE To utilize real-time electrical impedance tomography to guide lung protective ventilation in an animal model of acute respiratory distress syndrome. DESIGN Prospective animal study. SETTING Animal research center. SUBJECTS Twelve Yorkshire swine (15 kg). INTERVENTIONS Lung injury was induced with saline lavage and augmented using large tidal volumes. The control group (n = 6) ...
متن کاملAssessment of regional ventilation in acute respiratory distress syndrome by electrical impedance tomography.
Mechanical ventilation in acute respiratory distress syndrome (ARDS) incurs a risk of ventilator-associated lung injury (VALI) from inhomogeneous conditions and different properties of dependent and non-dependent lung regions at risk of atelectasis and overdistension, respectively. Electrical impedance tomography (EIT) offers regional ventilation assessment to optimise treatment with mechanical...
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INTRODUCTION Respiratory syncytial virus (RSV) lower respiratory tract disease is characterised by narrowing of the airways resulting in increased airway resistance, air-trapping and respiratory acidosis. These problems might be overcome using helium-oxygen gas mixture. However, the effect of mechanical ventilation with heliox in these patients is unclear. The objective of this prospective cros...
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BACKGROUND Lung failure after acute lung injury remains a challenge in different clinical settings. Various interventions for restoration of gas exchange have been investigated. Recruitment of collapsed alveoli by positive end expiratory pressure (PEEP) titration and optimization of ventilation-perfusion ratio by prone positioning have been extensively described in animal and clinical trials. T...
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